Presented for research literature review only Inoue M et al
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Depletion of Glutathione: Several factors can lead to a depletion of glutathione levels in the body: 1
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Moreover, it was reported that supplementing the diet with the antioxidants N -acetylcysteine and vitamin E markedly increases tumor progression and reduces survival in mouse models of B-RAF- and K-RAS-induced lung cancer, by reduction of ROS, DNA damage, and p53 expression (Sayin et al., 2014)